Jan 22, 2016

Possible Association Between Zika Virus Infection and Microcephaly — Brazil, 2015

by
Lavinia Schuler-Faccini
,
MMWR. Morbidity and Mortality Weekly Report
  • Investigates the possible association of microcephaly with Zika virus infection during pregnancy and presents a registry for incident microcephaly cases (head circumference ≥2 standard deviations [SD] below the mean for sex and gestational age at birth) and pregnancy outcomes among women suspected to have had Zika virus infection during pregnancy
  • Finds that among a cohort of 35 infants with microcephaly born during August–October 2015 in eight of Brazil’s 26 states and reported to the registry, the mothers of all 35 had lived in or visited Zika virus-affected areas during pregnancy, 25 (71%) infants had severe microcephaly (head circumference >3 SD below the mean for sex and gestational age), 17 (49%) had at least one neurologic abnormality, and among 27 infants who had neuroimaging studies, all had abnormalities
  • States that further studies are needed to confirm the association of microcephaly with Zika virus infection during pregnancy and to understand any other adverse pregnancy outcomes associated with Zika virus infection