The crash occurred around 9:30 a.m. EST.
“A burst of snow affected the interstate around or just before the time of the wreck,” AccuWeather Senior Meteorologist Dave Samuhel said. "Temperatures were around 25-26 F at the time."
The visibility was reported to be under a quarter of a mile at the nearby town of Howell, at 10 a.m. EST, Samuhel added.
Several other major pileups were reported in the Northeast on Thursday.
In Ohio, a portion of I-90, east of Cleveland, was shut down for more than 14 hours after a 50-vehicle pileup occurred Thursday afternoon. Twenty people were injured and the highway was reopened Friday morning, according to the Associated Press.
Another accident that was blamed on lake-effect snow occurred in northwest Pennsylvania. Up to 50 or 60 vehicles were involved in the accident early Thursday on I-90 in Erie County. At least 15 people were hurt in the crash.